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It is FDA-approved for individuals with a body mass index (BMI) of 30 or higher, or those with a BMI of 27 or higher who have at least one weight-related condition such as type 2 diabetes or high blood pressure
This class of medications treats type 2 diabetes and obesity
The mechanistic gap in the Retatrutide vs Tirzepatide comparison is therefore not merely quantitative (one more receptor) but qualitatively significant in terms of metabolic coverage and fat oxidation pathways
But people with reduced gastric motility from semaglutide may notice mild bloating or stomach discomfort if they take a large dose on an empty stomach
Rustenbeck, I
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